The Rise of DeSci: From Cognition to Understanding

1. The Evolution of DeSci

1.1 Introduction to DeSci

Pain Point:

The academic community has long faced the issue of lagging infrastructure in terms of IP maintenance, dissemination, ownership rights, and profit distribution of research results. In the complex realm of knowledge sharing and discovery, balancing security, transparency, incentive mechanisms, and accessibility has always been a challenge. The centralized verification systems that traditional models rely on may limit inclusivity and broad participation. Furthermore, existing systems fail to adequately reward or recognize knowledge contributions, affecting the development of comprehensive and collective knowledge bases.

Solution:

The core concept of DeSci is to provide equal access to various levels of science and knowledge for everyone, and to ensure the openness and transparency of the scientific research process. It aims to create an ecosystem that encourages knowledge contributors to share research results, while allowing anyone to browse and even iterate on this content without permission.

This new type of scientific research system has the following characteristics:

• Fund allocation is determined by the public through mechanisms such as DAOs, no longer controlled by small closed groups.
• Promote dynamic cooperation of resources globally and break through the limitations set by traditional institutions.
• Fund flow is more transparent and efficient, emphasizing token and reputation incentive mechanisms.
• Knowledge contributors can transparently allocate intellectual property, encouraging the sharing of all research data including failed experiments.

Doubts about DeSci 1.2

DeSci aims to establish an ecosystem for scholars to share academic research and obtain IP ownership, but for ordinary users, the sense of participation is limited to easier access to academic research. Essentially, the ivory tower of academia has not yet been broken, and the core players are still top scholars.

For ordinary people, there are rarely opportunities or needs to engage with academic reports outside of their school years. We must acknowledge that the ability to contribute valuable academic IP is still held by a few.

This is precisely the challenge facing DeSci - it is overly idealistic and fails to fully realize the true value of web3, namely community effects and an efficient economic system. The foundation of DeSci should be a vibrant ecosystem based on an efficient token system and strong community effects, rather than just an open knowledge contribution platform. If users cannot truly participate, then the token economy and ecosystem will struggle to sustain development.

Therefore, it is clearly not enough to have scientists as the core players, as this cannot form a sustainable mechanism.

2. Redefining DeSci

2.1 In-depth Understanding of DeSci

Knowledge is not equivalent to science

DeSci should not be limited to the realm of scientists, but should aim to lower the barriers for the general public to access science. Therefore, we should avoid overusing the term "science" and mention "knowledge" more often. "Science" sets a natural barrier for DeSci, while "knowledge" can encompass data in any form and field.

Contributing knowledge in one's professional field or areas of interest is itself very appealing and can easily lead to a viral effect. The expansion of the concept of "science" makes community participation possible and allows web3 to maximize its value.

DeSci should be a pyramid structure that classifies participants and contributors in the knowledge-sharing full chain into different levels, where each role is indispensable. Scholars, as participants at the top of the pyramid, contribute the most core value of DeSci and bring explosive points to the project. Taking new drug development as an example, if DeSci can participate in or facilitate the launch of a certain drug, the impact on the entire industry and project will be enormous. Community users, as participants at the bottom of the pyramid, also have their unique roles; they maintain the efficient operation of the entire ecosystem and economic system.

2.2 The Cornerstone of DeSci - BIO

2.2.1 Introduction to BIO

BIO Protocol is a decentralized scientific financial infrastructure aimed at promoting biotechnology innovation through community collaboration. It provides tools for the global community (, including patients, scientists, and biotechnology professionals ), for funding, developing, and governing scientific intellectual property, accelerating the commercialization of biotechnology research.

Its core function is to support decentralized organizations in biotechnology - BioDAOs.

2.2.2 In-depth Analysis of BIO

1) Technical Details

The technology stack and architectural design of the BIO Protocol are aimed at supporting the tokenization of biotechnology IP and on-chain governance.

• Develop customized public blockchains to ensure the transparency, verifiability, and security of the biological science technology and its development, commercialization, and transaction processes, while reducing transaction costs.
• The IP-Token mechanism based on smart contracts creates independent tokens for each IP asset, defining its ownership and transaction rules.
• Adopting a DAO-based architecture, members vote to manage and fund research projects using BIO tokens.

2) Operation Model Analysis

BioDAO

BioDAOs are decentralized autonomous organizations within the BIO Protocol ecosystem, each focusing on a specific scientific field. The BIO Protocol provides BioDAOs with:

1. Funding Support: Provide startup capital for the approved BioDAO.
2. Liquidity Support: Provide on-chain liquidity, allowing BioDAOs to focus on scientific research.
3. Governance: Participating in the decision-making of multiple BioDAOs through the meta-governance layer.
4. IP commercialization: Helping BioDAOs convert research outcomes into tradable intellectual property assets.
5. Standardized Framework: Provides a standard framework for the creation and operation of BioDAO.

Curation Mechanism

The curation mechanism of BIO Protocol aims to select and support the most promising BioDAOs to join the ecosystem:

• Application Process: New BioDAO submits an application to join the ecosystem.
• Voting Support: BIO token holders lock their tokens to gain voting rights ( vBIO ), and vote for candidate BioDAO.
• Curation Rewards: vBIO holders who successfully support will receive priority investment opportunities and privileges.
• Ecological Integration: Full support for the BIO Protocol through the curation of BioDAO.

Reward Mechanism

Bio/Acc provides rewards in the form of BIO tokens, covering multiple scenarios:

• Initial Token Auction
• Research funding ( IP token issuance )
• Launch of IP-related consumer products
• The product has entered the clinical trial phase.

At the same time, it also directly rewards BioDAO product users:

• Participate in clinical trials or self-report health data
• Use/Buy related products

IP-Token

• BioDAOs develop and hold the ownership of IP tokens.
• IP Token holders can obtain:
  • Governance rights: Participate in IP development, management, and licensing decisions
  • Priority Access: Priority or preferential access to relevant innovations and collaboration opportunities

2.2.3 The Investment Value of BIO

BIO has built the largest DeSci platform to date, commercializing scientific research with financial value while ensuring safety and transparency. The BIO subnet (, selected by the community, commercializes the value created by users, such as vitaDAO ), and rewards the users. $BIO continuously captures the value created by all DeSci subnets, making it the most valuable token in this field. In the long run, the demand for health and longevity will continue to increase, and BIO has significantly lowered the participation threshold in related fields, making it worthy of long-term attention.

The product has undergone a long period of accumulation and iteration, with star projects like vitaDAO emerging in the ecosystem, proving the feasibility of its operating model and market demand. The founding team has rich experience in scientific research and the web3 field, and holds top influence in the DeSci sector.

3. Future Outlook of DeSci

The potential of DeSci goes far beyond scientific research or drug discovery. By taking into account the concept of co-building knowledge, DeSci is actually constructing a vast dynamic database.

The Combination of DeSci and AI

DeSci should fragment knowledge and create a system where everyone can participate in knowledge co-construction. This complements the community attributes of web3, facilitating the organization of data across different fields, such as Gym DAO, Longevity DAO, etc. It can even organize bounty task DAOs to collect unsystematic data that retail investors can access.

The charm of DeSci lies in its ability to aggregate individuals' limited but valuable knowledge and data into scalable datasets, producing an effect where 1+1 > 2. To truly establish such a web3-based knowledge repository, the primary task is to develop the community and expand the user base to generate a network effect.

The motivation for users to participate and hold tokens comes from contributing data by joining data organizations through staking, earning incentives or staking rewards. High-value data will be referenced or associated more, and correspondingly, data organizations will receive more external income and native incentives. This mechanism not only encourages user participation but also promotes the improvement of data quality.

In this vast system, it allows for the existence of users who contribute less or have lower quality, as they can provide data to participate in staking, hoping to earn the lowest tier of community incentives. This inclusive design does not affect the overall operation of the system, and may even bring unexpected contributions.